张方林

发布时间:2019.01.17 10:08


姓名:张方林,

出生年月:1977.07

学历/学位:博士

职称:教授 、博士生导师

Emailfanglinzhang@whut.edu.cn


教育经历

2002.9 -2008.6  华中科技大学、无机化学、博士学位、导师龚跃法教授

1995.9 -1999.6  华中科技大学、应用化学、学士学位

工作经历

2011.7-至今 武汉理工大学亚博网站信誉有保障的   副教授、教授、博士生导师

2014.9-2015.9 美国Scripps研究所   访问学者   合作导师:余金权院士

2008.7-2011.9 华中科技大学生科院 博士后     合作导师:杨祥良教授

1999.7-2002.8 中国乐凯胶片集团公司研究院    研发工程师

研究领域

长期从事有机合成与药物合成研究,具有丰富的合成经验与理论,专注惰性碳氢键的官能化及功能结构的新路线开发与性能研究。(欢迎药学、化学、化工及相关交叉学科的本科生和研究生加入)

教学科研

讲授本科生的制药工艺学,以及研究生的高等有机合成。近年来在ScienceJACS等期刊发表论文二十余篇。主持国家自然科学基金2项、国家重点研发计划子课题1项、湖北省自然科学基金1项、深圳市基础研究基金以及多个企业横向课题。

代表性论文

[15]Fang-Lin Zhang#, Kai Hong#, Tuan-Jie Li#, Hojoon Park, Jin-Quan Yu*. Functionalization of C(sp3)–H bonds using a transient directing group. Science,2016, 351, 252-256.

[14] Ming La, Dandan Liu, Xuerong Chen, Fang-Lin Zhang,* and Yirong Zhou. Monodentate Transient Directing Group-Assisted Palladium-Catalyzed Direct ortho-C–H Iodination of Benzaldehydes for Total Synthesis of Hernandial Org. Lett., 2021,23, 9184–9188

[13] Qun-Liang Zhang, Qin-qin Yu, Li Ma, Xuelian Lu, Qing-Tian Fan, Tian-Shun Duan, Yirong Zhou*, and Fang-Lin Zhang*. A Metal-Free Visible-Light Photoredox Construction and Direct C–H Functionalization of Pyridines: Green Synthesis of Polysubstituted Picolinaldehydes J. Org. Chem. 2021, 86, 17244–17248

[12] Yongdi Wu, Na Liu, Meifang Qi, Huihao Qiao, Xuelian Lu, Li Ma, Yirong Zhou,* and Fang-Lin Zhang*. Monodentate Transient Directing Group Assisted Ruthenium(II)-Catalyzed Direct ortho-C−H Imidation of Benzaldehydes for Diverse Synthesis of Quinazoline and Fused Isoindolinone Org. Lett., 2021,23, 3923−3927

[11] Xi-Hai Liu, Hojoon Park, Jun-Hao Hu, Yan Hu, Qun-Liang Zhang, BaoLong Wang, Bing Sun, Kap-Sun Yeung,Fang-Lin Zhang*, and Jin-Quan Yu*. Diverse ortho-C(sp2)-H Functionalization of Benzaldehydes using Transient Directing Groups. J. Am. Chem. Soc,2017,139, 888-896

[10] Huihao Qiao, Bing Sun, Qinqin Yu, Yi-Yong Zhou*, Fang-Lin Zhang*. Palladium Catalyzed Direct Ortho-C-H Selenylation of Benzaldehydes Using Benzidine as a Transient Directing Group. Org. Lett., 2019,21, 6914-6918.

[9] Li, Feng; Zhou, Yirong; Yang, Heng; Wang, Ziqi; Yu, Qinqin; Fang-Lin Zhang*. Monodentate Transient Directing Group Enabled Pd-Catalyzed Ortho-C-H Methoxylation and Chlorination of Benzaldehydes Org. Lett., 2019,21, 36923695

[8] Wang, Ziqi; Dong, Wendan; Sun, Bing; Yu, Qinqin*; Fang-Lin Zhang*. Cascade reaction for the synthesis of polycyclic aromatic hydrocarbons via transient directing group strategy. Tetrahedron2019, 75, 4031-4041.

[7] Yang, Heng; Liu, Dandan; Yu, Qinqin; Xia, Siyu; Yu, Dan; Zhang, Mao; Sun, Bing*; Fang-Lin Zhang*. DBU-Promoted Intramolecular Crossed Aldol Reaction: A Facile Access to Indane-Fused Pyrrolidine. European Journal of Organic Chemistry2019, 852-856.

[6] Feng Li, Yirong Zhou; Heng Yang, Dan Dan Liu, Bing Sun, Fang-Lin Zhang*. Assembly of Diverse Spirocyclic Pyrrolidines via Transient Directing Group Enabled Ortho-C(sp2)–H Alkylation of Benzaldehydes, Org. Lett., 2018,20, 146-149.

[5] Ming Tang, Qinqin Yu, Ziqi Wang, Chen Zhang, Bing Sun, Ying Yi,* andFang-Lin Zhang*. Synthesis of Polycyclic Aromatic Hydrocarbons (PAHs) via a Transient Directing Group Org. Lett. 2018,20, 7620-7623

[4] Jun-Hao Hu; Yun-Chao Xu; Dan-Dan Liu; Bing Sun; Ying Yi*;Fang-Lin Zhang*. Direct stereoselective construction of cyclopropane α-amino acid with contiguous quaternary centers via [4 + 2] annulation reaction.RSC Advances,2017, 7, 38077-38080.

[3] Yi-Feng Wang, Wen-Gang Xu, Bing Sun, Qin-Qin Yu, Tuan-Jie Li*, andFang-Lin Zhang*. Monodentate Transient Directing Group Assisted Pd-Catalyzed Direct Dehydrogenative Cross-Coupling of Benzaldehydes with Arenes toward 9‑Fluorenones. J. Org. Chem. 2019, 84, 13104

[2] Wendan Dong, Zhun Hu, Ziqi Wang, Bing Sun, Xueqiong Zhang*, Fang-Lin Zhang*. One-pot synthesis of benzofluorene fused aromatic hydrocarbons Tetrahedron Letters 2019, 60, 151299

[1] Yong, Qiyun; Sun, Bing*; Fang-Lin Zhang*. Palladium-catalyzed ortho-C(sp2)-H bromination of benzaldehydes via a monodentate transient directing group strategy. Tetrahedron Letters2019, 60, 151263.


   

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